I use different settings for Facebook, 500px, Flickr and my website when I export photos from Lightroom.
Facebook resizes photos, unless they are already of one of the pre-defines sizes:
Regular photos | 720 px, 960 px, 2048 px |
Cover photos | 851 px by 315 px |
I usually export photos for Facebook and my own website at 1000 pixels along the long side and use standard screen sharpening. I don’t worry about resizing. Here is a sports photo page that Armando and I use to send updates on our photo shoots, and the photos there are saved with these settings: APshutter.com.
For Flickr and 500px, I upload full resolution photos, which serves as an additional backup. I find that both sites do good job in terms of resizing and displaying the photos.